Education Archive

Molecules meet morphology in lung cancer detection

Automated detection of genetic abnormalities combined with sputum cytology is a sensitive predictor of lung cancer, according to a study reported in the journal Modern Pathology.

A combination of cytological atypia and genetic abnormalities for 3p22.1 and 10q22.3 (detected by fluorescence in situ hybridisation) achieved 74% sensitivity and 82% specificity, compared with only 37% sensitivity and 87% specificity when cytology alone was used.

http://www.ncbi.nlm.nih.gov/pubmed/18500269