Education Archive

Study to determine the minimum cellularity required for the reliable assessment of Liquid Based Cervical (LBC) cytology samples

The number of cells required for LBC samples to be deemed adequate remains the subject of debate. There is a risk that samples may be described as negative when they are really inadequate and that abnormalities could therefore be missed.

An adequate LBC sample is one in which sufficient numbers of cells are present to allow the detection of an abnormality were it to be present. This study aims to establish the threshold of cellularity which will minimise the risk of false negative reports.