Education Archive

LBC improves detection of glandular abnormalities

Reporting rates for glandular neoplasia in 464,754 cervical samples reported at six UK laboratories in 12-month periods before and after the implementation of SurepathTM LBC processing are compared. The introduction of LBC processing is seen to have resulted in a significant increase in the detection rate for endocervical glandular neoplasia while maintaining high levels of reporting specificity.

The authors suggest the following underlying reasons for the observed improvement in detection of endocervical glandular neoplasia:
1. More effective sampling of the endocervical canal as a result of changed sampling devices (from wooden spatulae to broom style samplers)
2. More representative transfer of cells from the sampling device to the liquid medium used for processing 
3. Improved morphological presentation of endocervical abnormalities particularly evident with Surepath samples.

http://onlinelibrary.wiley.com/doi/10.1002/dc.21471/full