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Diagnostic accuracy of guided cervical biopsies

A prospective study in which colposcopically guided cervical biopsies and cone excision were performed in a single procedure, the sensitivity and specificity of biopsies for detecting CIN2+ were 66.2% and 95.0%, respectively. While the positive predictive value was 98.5%, the negative predictive value was only 35.5%. So, cervical biopsies are reliable for confirming cytologically detected high grade disease but are relatively poor at excluding it.