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Amplification of the human telomerase gene in liquid-based preparations is associated with cervical dysplasia and carcinoma

Fluorescence in situ hybridization (FISH) has been successfully applied to liquid-based cytology preparations to analyse the amplification of the human telomerase gene (TERC) in normal and abnormal cervical samples. The results showed a significant association betwen gene expression levels and grade of abnormality, thus providing a potentially useful prognostic marker.