Education Archive

Amplification of the human telomerase gene in liquid-based preparations is associated with cervical dysplasia and carcinoma

Fluorescence in situ hybridization (FISH) has been successfully applied to liquid-based cytology preparations to analyse the amplification of the human telomerase gene (TERC) in normal and abnormal cervical samples. The results showed a significant association betwen gene expression levels and grade of abnormality, thus providing a potentially useful prognostic marker.



http://journals.lww.com/intjgynpathology/pages/articleviewer.aspx?year=2010&issue=03000&article=00008&type=abstract