HPV-based screening more effective than cytology in preventing invasive cervical cancer
Latest results from the Italian NTCC randomized controlled trial:
Among women aged 35—60 years, one round of HPV screening detects twice as many cases of high grade CIN than cytology. By the second round detection rates are dramatically reduced to about half that of cytology (interpreted as early detection of largely non-regressive disease).
Among younger women however, HPV testing detects as much as four times the rate of high grade disease in the first round and just over half that detected by cytology in round two (interpreted as over-detection of regreesive lesions).
Conclusion: HPV primary screening in the over 35s is more effective than cytology in preventing invasive cervical cancer.